An innovative technology for continuous real-time In-process nanoparticle size characterization from Inprocess LSP for quantification of nanoparticles, liposomes, nanosuspensions, nanoemulsions etc. in pharmaceutical industry or research applications.
|Usage/Application||Process monitoring tools for nanosuspensions & nanoemulsions etc.|
|Features||Continuous size characterization during processing,real-time process feedback & high speed detection|
|Particle Size Range||10 - 1000 nm|
|Detection||Back-scattering (180 Degree)|
|Central Wavelength||1300 nm|
|Maximum Process Flow||6 L/min for polystyrene particles (100 nm,5 mg/mL)|
|Particle Size Distribution||Intensity based and volume based,d10 / d50 / d90|
The NanoFlowSizer is an innovative system for continuous, real-time nanoparticle size characterization and a powerful non-invasive Process Analytical Tool allowing close monitoring of particle size characteristics in your process in either development laboratories, pilot plants or commercial operations, without the need of sampling.
Standard DLS measurements need to be performed under static conditions ensuring that particle movement is solely caused by Brownian motion and not influenced by other factors like liquid flow. Additionally, standard DLS cannot be applied to the turbid suspension which are often encountered in industrial or process environments.
These limitations can be overcome by the new concept of Spatially Resolved Dynamic Light Scattering (SR-DLS) which allows particle size characterization in process flows and for highly turbid suspensions. The NanoFlowSizer technology is based on low coherence interferometry providing light scattering information as function of optical path-length in process flows. The depth resolved light scattering holds information on particle movement caused by both Brownian motion as well as flow rate. The contribution to scattered light fluctuations due to Brownian motion is used for calculation of the particle size characteristics.
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